Formation Cells
For high-molecular, chemically pure immunomodulators obtained by directed chemical synthesis, is the drug Polioksidoniy. It is is N-oxidized derivative poliegilenpiperazina with a molecular weight of about 100 kD. The drug has a pharmacological effect on a wide range of body: disease-modifying, detoxifying, antioxidant and membranoprotektornym. To drugs, characterized by distinct immunomodulatory properties, should include the interferons and interferon inducers. Interferons as an integral part of the cytokine network organism are immunoregulatory molecules that have an effect on all cells of the immune system.
Pharmacological effect of immunomodulators. Immunomodulators of microbial origin. In the body, a prime target for immunomodulators of microbial origin are phagocytic cells. Under the influence of these drugs enhanced functional properties of phagocytes (increased phagocytosis and intracellular Keeling sequestered bacteria), increased production of proinflammatory cytokines required for the initiation of humoral and cellular immunity. This may result in increased production of antibodies that activate the formation of antigen-specific T-helper and T-killers.
Immunomodulators thymic origin. Naturally, in accordance with the name of the main targets of immunomodulators thymic origin are T-lymphocytes. At initially lower rates of a number of drugs increase the number of T cells and their functional activity. Pharmacological effect of the synthetic thymic dipeptide Timogen is to raise cyclic nucleotides, by analogy with the effect of thymic hormone timopoetina, which leads to stimulation of differentiation and proliferation of T-cell precursors into mature cells. Immunomodulators bone origin. By immunomodulators derived their bone marrow of mammals (pigs or calves) is Myelopid. The structure consists of six myelopid specific bone marrow mediators of immune response, called myelopeptides (MP). These substances have the ability to stimulate various parts of the immune response, especially humoral immunity. Everyone has a certain myelopeptide biological action, a set of and which accounts for its clinical effect. MP-1 restores the normal balance of T-helper and T-suppressors. MP-2 inhibits proliferation of malignant cells and significantly reduces the ability of tumor cells produce toxic substances that inhibit the functional activity of T lymphocytes.
